Zetasizer Ultra

概述

Zetasizer Ultra 融合了功能强大的 DLS 与 ELS 系统，它采用了非侵入背散射 (NIBS) 和独特的多角动态光散射 (MADLS) 技术来测量颗粒与分子大小。

NIBS 的多用性和灵敏度可适用广泛的浓度范围，而 MADLS 则能让您在这些关键测量当中更精细地了解样品粒度分布。

Zetasizer Ultra Red Label 的 MADLS 扩展功能可直接分析颗粒浓度。颗粒浓度的测量适合于广泛的材料，无需或只需很少稀释，并且使用快捷，这一切使其成为一种理想的筛选技术。这是 Zetasizer Ultra 的一项独特功能，甚至可以运用于以前非常难测量的病毒和类病毒颗粒 (VLP) 等样品。

一系列可抛弃和可重复使用的样品池可优化不同样品体积和浓度的测量，其中包括新的低容量可抛弃粒度测量池套件，由于它可以抑制对流，所以既能进行样品量小到 3 µL 的粒度测量，也扩展了DLS 测量的粒度上限范围

马尔文帕纳科 OmniTrust: 监管环境下的合规性解决方案

具有恒流模式的M3-PALS可以在高导电介质中测量Zeta电位和电泳迁移率
“自适应相关”算法能生成可靠且可重复的数据，同时计算速度超过以往的两倍，可在减少样品制备的情况下更快速地执行更多可重现的粒度测量，实现更具代表性的样品视图
以样品为中心的ZS Xplorer软件可以实现灵活的指导式使用，并可轻松构建复杂的模型
可选的 MPT-3 自动滴定仪可帮助研究 pH 值变化的影响
通过深度学习实现的数据质量系统可以评估粒度数据质量问题，并针对如何改进结果提供明确的建议
新的样品助手附件减少了手动更换样品的时间，而不影响数据质量
滤光片转盘提供荧光滤光片以及垂直和水平偏振片，以实现分析灵活性
可抛弃型毛细管粒度测量样品池提供了无损、低容量（最低 3 µL）分析，并且粒度上限范围可达到 15 μm

Dive deeper with these free resources

Recorded webinar

Zetasizer Ultra and Pro - Demo at your desk

Recorded webinar

Adaptive Correlation: How to get better DLS data with less time and effort.

Recorded webinar

Drug Delivery Vector Characterization Using Zetasizer Advance

Key applications

Zetasizer Ultra is ideal for a wide range of applications across many industries, including pharmaceuticals and mining. Find out more below about the key applications for Zetasizer Ultra.

Lipid nanoparticles

Zetasizer Ultra provides rapid, reliable characterization of lipid nanoparticles and viral vectors.

Measure particle size, concentration, polydispersity, and zeta potential to assess stability, yield, and surface charge across formulation development and manufacturing workflows to refine processes and ensure batch-to-batch reproducibility.

Viruses

Speed up analysis of viruses with fast size and concentration measurements. MADLS^® technology enables simultaneous size and concentration measurement, determining viral titer and distribution in minutes.

Monitoring these key parameters with Zetasizer Ultra helps you optimize processes, maintain quality, and reduce development time.

Ceramics

The strength of ceramics is linked to particle size, and the Zetasizer Ultra is ideally placed to measure this. Al₂O₃ samples are often made of differently-sized particles which can easily be identified using MADLS.

In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.

Resources

Whitepaper

Improved component resolution with Multi-Angle DLS (MADLS)

Whitepaper

如何选择光散射仪器进行纳米颗粒粒度和 Zeta 电位测量

Recorded webinar

Drug Delivery Vector Characterization Using Zetasizer Advance

Excellent system for characterizing nanoparticles in terms of their Physicochemical properties (size, concentration, polydispersity, and zeta potential). I like the system because it consumes only a few microliters of precious samples to determine and analyze all the properties mentioned above. I highly recommend this system for particle analysis."

Ashwini Mishra — AAVinue Inc.

测量原理：	非侵入背散射 (NIBS) 动态光散射动态光散射（90° 和 13°）多角动态光散射 (MADLS)
测量角度	173°, 13°, 90°
测量范围：	0.3 nm - 15 μm ²
最小样品容积：	3 μL
浓度范围	最低样品浓度： Blue Label：0.2 mg/mL 15 kDa 蛋白质 Red Label：0.1 mg/mL 15 kDa 蛋白质 MADLS： 0.1 mg/mL 15 kDa 蛋白质 MADLS 颗粒浓度已启用？ Blue Label：否 Red Label：是最高样品浓度 ⁽³⁾： 40% w/v

测量原理：	混合模式测量，相分析光散射 (M3-PALS)，恒流模式
尺寸	3.8 nm – 100 μm
最小样品容积：	20 μL ⁴
浓度范围	红标Red Label: 1 mg/mL ⁽⁵⁾ 至 40% w/v ⁽⁶⁾ 蓝标Blue Label: 10 mg/mL ⁽⁵⁾ 至 40% w/v ⁽⁶⁾
样品导电范围	最高：260 mS/cm

分子量范围	300 Da – 20 mDa
测量原理：	静态光散射法，使用德拜图
精确度	+/- 10%

测量原理：	Blue Label：不适用 Red Label：MADLS - 颗粒浓度 (Mie)
浓度范围	Blue Label：不适用 Red Label：1x10⁸ 至 1x10¹² 颗粒/mL
校准类型	Blue Label：不适用 Red Label：仅限单点系统校准

检测器	雪崩光电二极管 (APD)
激光安全：	高性能He-Ne 气体激光器, 633 nm Blue Label：最大输出功率 4 mW Red Label：最大输出功率 10 mW
温度控制范围	0 °C - 120 °C ⁷
尺寸（宽, 长, 高）：	322 mm x 565 mm x 245 mm
重量	19 kg
功率	AC 100-240 V, 50-60 Hz, 4.0 A
能耗	最大 100 W，典型 45 W
环境条件	+10°C 至 +35°C，相对湿度 35% - 80%（无冷凝）
界面	USB 2.0 或以上版本
国际标准	国际标准化组织 ISO22412:2025 ISO13099-2:2025 美国药典（USP） 430 – 动态光散射粒径分析 432 – 电泳光散射法测定 ζ 电位 729 – 注射用脂质乳剂的粒径分布 1153 – 含纳米材料的药品 1154 – 脂质体药品 1430 – 基于散射现象的分析方法——通则 ASTM D4001 E2490 E2865 E3247

注解	1 - 用水作为样品分散剂 2 - 使用低容量可抛弃粒度样品池和扩展粒度分析可以测试粒度大于10 µm ；取决于样品和样品制备 3 - 取决于样品 4 - 使用扩散屏障技术 5 - 使用 15 kDa 蛋白质测量 6 - 使用胆汁酸测量 7 - 温度低于露点时，需要干燥氮气吹扫测量池 8 - 准确度 0.1°C（25°C 时）、0.2°C（0°C 时）、0.5°C（90°C 时） 9 - MADLS的建议上限尺寸范围是直径500 nm

One platform, three critical answers

When your work depends on reliable, high-quality data, you need confidence in every measurement.

Zetasizer Advance Ultra gives you that confidence, combining speed, sensitivity, and flexibility to deliver reproducible results - even when your samples are complex, your users aren’t light scattering experts, or your timelines are tight.

Smarter measurements, faster

Adaptive Correlation automatically adjusts each measurement according to the sample behavior, revealing your sample’s steady state faster, with less time spent re-optimizing methods for changing sample types.

What’s more, our unique machine learning-powered Data Quality Guidance flags results as good, suspect, or poor – and recommends next steps to improve results data quality while eliminating the guesswork.

Deeper insight with multi-angle DLS (MADLS®)

Our patented MADLS^® technology provides high-resolution particle size and concentration measurements, revealing fine details single-angle systems can’t.

MADLS combines multiple detection angles into angle-independent results in minutes, so you’ll quickly see more of what matters - from minor populations to subtle shifts in stability – with data appearing on screen in minutes.

[Available with Red model only]

Low-volume, high-value precision

Measure from just 1 µL of material with our low-volume sizing cell, ideal for scarce or high-value samples.

Preserve sample integrity with our patented diffusion-barrier method, protecting sensitive materials from dilution and handling effects.

More results with less hands-on time

Automate the measurement of up to 120 samples from a single setup with Zetasizer Sample Assistant.

Measurements run unattended while your team focuses on higher-value work – or even overnight. Results are waiting when you return.

Zetasizer Sample Assistant is an optional accessory that works with all models in the Zetasizer Advance range.

Seamless compliance in regulated environments

For regulated environments, all Zetasizer Advance systems pair with OmniTrust to enable 21 CFR Part 11 compliance, electronic signatures, and complete audit trails.

What our customers say

Zetasizer Ultra Trusted by scientists worldwide to deliver reliable, reproducible data. Don’t just take it from us - here’s what our customers say.

Excellent system for characterizing nanoparticles in terms of their Physicochemical properties (size, concentration, polydispersity, and zeta potential). I like the system because it consumes only a few microliters of precious samples to determine and analyze all the properties mentioned above. I highly recommend this system for particle analysis.

Ashwini Mishra — Director Process Development | AAVinue Inc

Shortens the test time, provides early warning quality control, optimizes the test process, and completes the material inspection and verification.

Liu Lei — China Banknote Ink Co., Ltd

I've been using Malvern Panalytical’s Zetasizer since 2014. I used two other brands of DLS instruments, but none of them were as user-friendly as the Zetasizer.

Tugba Yildiz — Senior Scientist, LNP Formulations | TScan Therapeutics

Reliable and repeatable results. This equipment makes life easier when you have to perform hundreds of measurements. The device is simple and pleasant to use, it is easy to teach new people how to use it. Service at the highest level, always ready to help. In addition, the company regularly organizes free webinars with specialists in the operation of the apparatus and the possibilities of its use.

Paweł Misiak — Researcher | University of Bialystok

	白金计划	黄金计划	青铜计划
年度 PM/PV 测试	是	是	否
电话/邮件支持	是	是	否
优先响应	是	是	否
紧急停机上门服务*	是	是	否
包含零件	是	否	否
在线学习**	是	是	否
技术和软件支持	是	是	是
IQ/OQ（制药）***	是	是	是

光散射系统

概述

特征

Dive deeper with these free resources

Key applications

Resources

参数指标

附件

系统增强

样品池选件

One platform, three critical answers

Smarter measurements, faster

Deeper insight with multi-angle DLS (MADLS®)

Low-volume, high-value precision

More results with less hands-on time

Seamless compliance in regulated environments

What our customers say

用户手册

软件下载

支持

帮助台

培训

软件下载

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世界上最先进的光散射系统。