| 00:00:00 | Welcome |
| 00:00:11 | Introduction |
| 00:01:48 | Gel-permeation chromatography |
| 00:02:22 | Multi-detector SEC |
| 00:03:12 | RI Detection |
| 00:03:41 | UV Detection |
| 00:04:26 | Static Light Scattering – Molecular Weight |
| 00:05:55 | How does intrinsic viscosity relate to structure? |
| 00:07:52 | What are the Multiple Detectors responding to? |
| 00:08:39 | The multi-detection pyramid |
| 00:10:35 | SEC & Triple Detection Summary |
| 00:11:04 | PLGA |
| 00:11:27 | PLGA |
| 00:13:51 | PLA |
| 00:15:39 | PLGA 50:50 |
| 00:16:08 | PLGA 50:50 - 8 repeat injections |
| 00:16:55 | PLA/PLGA copolymers |
| 00:18:46 | PLA/PLGA |
| 00:20:21 | PLA/PLGA |
| 00:21:29 | Solvent compatibility |
| 00:23:40 | Solvent compatibility |
| 00:24:05 | Solvent compatibility |
| 00:25:12 | Drug delivery application: Polyglutamate and Doxorubicin |
| 00:25:20 | Drug Delivery – Polyglutamate & Doxorubicin |
| 00:26:53 | PG |
| 00:27:14 | PG & PG-Dox overlays |
| 00:28:29 | Doxorubicin concentration calibration curve |
| 00:29:11 | Conjugate Dox content |
| 00:30:43 | Molecular weight |
| 00:31:42 | Polymer and conjugate structure |
| 00:33:43 | Summary |
| 00:34:42 | Thank you for your attentionAny questions?Please type your questions in using the Q&A panel on the right side of your screen |
| 00:41:38 | Contact Information |
Correctly targeting a drug product’s delivery location and defining its release profile are critical challenges and the subject of a great deal of research. The role of polymers in drug delivery applications is growing, with particular emphasis on targeted controlled-release mechanisms and the development of nanoparticles used to contain or carry drug molecules.
This presentation focuses on the information provided by GPC/SEC about polymers used in drug delivery applications. In the case of polymer conjugates, GPC/SEC can also be used to characterize the end-product; for example, by measuring the amount of drug conjugated to the polymer.
The webinar includes a short overview of GPC/SEC technologies used to make these measurements and covers some key application examples showing the technology’s utility. Mark also explains how DLS can be used to characterize nanoparticles made for drug delivery applications and how these two techniques together can accelerate research in this key application area.
This presentation focuses on the information provided by GPC/SEC about polymers used in drug delivery applications. In the case of polymer conjugates, GPC/SEC can also be used to characterize the end-product; for example, by measuring the amount of drug conjugated to the polymer.
The webinar includes a short overview of GPC/SEC technologies used to make these measurements and covers some key application examples showing the technology’s utility. Mark also explains how DLS can be used to characterize nanoparticles made for drug delivery applications and how these two techniques together can accelerate research in this key application area.