Protein Stability Conference is coming to Colorado

With Pre-Conference Workshop on Biophysical Characterization and Particle Analysis

Date: July 17th – 20th.

We at Malvern know that protein stability is important in numerous disciplines, ranging from basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all the relevant areas can join to discuss the critical issues in the field. The 2017 Colorado Protein Stability Conference provides a unique forum for this exchange of information. The topics to be covered include protein folding, dynamics and thermodynamic stability; amyloidosis and protein aggregation; and stability, formulation, analysis and processing of therapeutic proteins.

The scientific sessions will consist of plenary lectures by leading researchers. In addition, contributed papers will be presented during a poster session.

Malvern Instruments is proud to sponsor a complimentary Workshop on Biophysical Characterization and Particle Analysis. During this workshop, you will have the opportunity to interact with technical experts and advanced users. A large range of instruments will be available for demonstration.  There will be time to troubleshoot issues, learn how to better understand your data (feel free to bring it along!), and to network with others using these techniques for stability profiling and characterization of particles.

There will be scientists with a wide range of interests in attendance on the day, and we welcome everyone, from novices to expert users.

Monday July 17^th

Workshop on Biophysical Characterization and Particle Analysis

• Roles of nano- and microparticles in adverse immunogenicity
  Merry Christie, US FDA
• Critical methods for counting and sizing subvisible particles
  Amber Fradkin, KBI Biopharma
• Automated Raman microscopy for characterization and identification of particles
  Kevin Dahl, KBI Biopharma
• Biophysical characterization for regulatory filings and comparability studies
  John Gabrielson, Elion Labs
• Differential scanning calorimetry for therapeutic protein product characterization and comparability studies
  Kelly Arthur, Elion Labs

 

Tuesday, July 18th, 2017:

Protein Folding, Dynamics, and Thermodynamic Stability

• Proteins under stress in folding and aggregation
  Ken Dill, Stony Brook Univ.
• Protein stability in cellular context: Physics meets evolution Eugene Shakhnovich, Harvard Univ.
• Protein folding and protein design
  Yang Zhang, Univ. of Michigan
• Dynameomics: From simulation of all protein folds to the design of amyloid inhibitors and diagnostics
  Valerie Daggett, Univ. of Washington
• Studying protein dynamics by hydrogen exchange mass spectrometry: From enzymes to molecular motors
  Lars Konermann, Univ. of Western Ontario
• Early discovery biophysical analysis to enable selection of better therapeutic molecules
  Annette Sievers, Pfizer
• Salt entropy contributions to protein solubility and the Hofmeister series
  Jeremy Schmit, Kansas State Univ.
• Characterizing the conformationally dynamic Beta Roll peptide domain and engineering it to participate in useful bimolecular interactions
  Scott Banta, Columbia Univ.
• Combining molecular models and scattering for antibody interactions from low to high protein concentration
  Chris Roberts, Univ. of Delaware

Amyloidosis and Protein Aggregation

• Metal induced protein agglomeration
  Yolanda Hedberg, KTH Royal Institute of Technology
• Chemical approaches to probe and manipulate amyloid assembly
  Steve Bourgault, Univ. of Quebec
• Protein misfolding and Type-2 diabetes: From basic biophysics to beta-cell death
  Dan Raleigh, SUNY Stony Brook

 

Wednesday, July 19th, 2017:

Poster session

Thursday, July 20th, 2017

Formulation, Analysis, and Processing of Therapeutic Proteins

• Scientific and regulatory considerations in evaluating aggregates in biotherapeutic products
  Rukman DeSilva, US FDA
• Multiple methods for characterization of particles
  Amber Fradkin, KBI Biopharma
• Characterization of sub-visible particles with multi-spectral imaging flow cytometry
  Christine Probst, Amnis – EMD Millipore
• Impurities and identity: what can the transcriptome tell us?Daniela Verthelyi, US FDA
• Reducing the costs of biologics combining modeling and high throughput screening of monoclonal antibodies
  Bruce Kerwin, Just Biotherapeutics
• Exploiting the biophysical properties of Centyrins for targeted delivery
  Karyn O’Neil, J&J
• New studies of protein drugs in plastic syringes
  Gerhard Winter, Ludwig-Maximilians Univ.
• Minimizing silicone levels in biopharmaceuticals
  Wolfgang Friess, Ludwig-Maximilians, Univ.
• Characterizing of adsorbed protein orientation and conformation, and their effects on bioactivity
  Robert Latour, Clemson Univ.
• Understanding surfactants – do or do not, there is no try
  Satish Singh, Lonza
• Probing the interface of protein stability analysis, formulation development and biosimilarity assessments
  David Volkin, Univ. of Kansas
• Impact of natural variations in freeze drying on process design and protein stability
  Mike Pika, Univ. of Connecticut

To foster exchange of information, attendance will be limited to the first 200 registrants, and there will be ample opportunity for informal discussions.

We look forward to seeing you in Colorado in July. Seats are filling up fast so don’t hesitate.