Liposomes: A 3-Part Tale!

Liposomes are attractive vehicles for drug payload delivery, among other nanoparticles helping to provide endless possibilities for tackling various pharmaceutical needs.  We provide solutions for the effective and optimal development of liposomes and other nanoparticles, which help ensure that only safe products reach consumers. 

Over the past 6 months, we have presented to and engaged with you through a three-part liposome webinar series, exploring a variety of topics and welcoming your questions.  As a single point of reference for these three webinars, this blog provides a brief summary of the different events. 

However, the engagement does not stop here with this blog!  Please contact us to further discuss your specific research needs. Our goal is to provide the best solutions for the challenges you face – to make your workflow smoother and more efficient, and to ensure your products are always safe and effective.  Be sure to reach out to your regional representative and learn more about how we can help. 

Here are the three webinars in chronological order:

Part 1: Explore deformulation and characterization of liposome-based drug products with Malvern Panalytical

• Learn about Malvern Panalytical’s range of technologies for formulation development, optimization, and quality control for liposomes
• Learn the best practices for following regulatory guidance and establishing Critical Quality Attributes (CQAs)
• You can view the Question and Answer blog for this webinar here. 

Part 2: How to scale liposomal formulations for large-scale production: From benchtop to GMP manufacturing

• We partnered with Precision Nanosystems to show you how microfluidics technology can accelerate the large-scale production of nanoparticles
• We showed how the Zetasizer can be used to optimize microfluidics settings and monitor particle size and polydispersity to ensure robust manufacturing of liposomes

Part 3: Physicochemical Characterization of Nanomedicines: Investigating surface characteristics of nanodelivery systems and their interactions with plasma

• We partnered with Dr. Jeff Clogston at the National Cancer Institute’s (NCI) Nanotechnology Characterization Laboratory (NCL). He reviews the methodology and analytical techniques used to characterize nanodelivery systems
• Dr. Clogston reviews techniques including dynamic and static light scattering, zeta potential, and asymmetric-flow-field flow fractionation (AF4)
• Dr. Clogston shows how these techniques are used to assess the stability of nanodelivery systems in plasma

Further reading:

• Industry page: Liposome- and nanoparticle-based drug product formulation
• Questions and Answers: Liposome-based drug products