| 00:00:00 | Welcome |
| 00:00:08 | Introduction |
| 00:01:25 | Why measure particle size (distribution)? |
| 00:01:39 | Abstract |
| 00:01:44 | Note in the title… |
| 00:03:38 | Why? |
| 00:05:04 | Heywood & Scarlett |
| 00:06:12 | BS and HH (and Stuart Bark on the LHS) |
| 00:07:03 | CQA’s and PFI’s |
| 00:08:14 | Critical to performance? |
| 00:09:26 | Why? Bulk Properties |
| 00:10:52 | Quality by Design |
| 00:11:29 | Why? |
| 00:13:18 | ‘Sample preparation’ |
| 00:15:56 | Why? |
| 00:17:20 | Why Measure Particle Size? |
| 00:18:10 | The complicated picture |
| 00:20:17 | The military factor/connection |
| 00:22:32 | Battlefield smokes |
| 00:24:09 | Fuel droplet injection in jet engines |
| 00:26:27 | Insecticide |
| 00:27:33 | Sprays and aerosols |
| 00:28:15 | Insecticide |
| 00:28:40 | Insecticide |
| 00:29:38 | Lung entry – therapeutic! |
| 00:30:53 | LD50 for Pasteurella tularensis |
| 00:31:46 | The importance of aerodynamic diameter |
| 00:32:40 | So long thin particles can penetrate the lungs |
| 00:33:32 | Forthcoming FDA standard |
| 00:33:51 | The dynamic nature of a spray event |
| 00:35:02 | Which leads us onto emulsions |
| 00:37:24 | Jean-Louis Salager – another gentleman |
| 00:38:25 | Andriy Kyrylyuk* – Slide 26 |
| 00:39:26 | Packing density |
| 00:40:10 | Road asphalt applications |
| 00:40:40 | Powders – why? |
| 00:42:06 | Why solids/powders? |
| 00:42:36 | Cement and (1-day) strength |
| 00:43:39 | Effect of particle size on tablet strength* |
| 00:44:08 | Why doesn’t my toilet fall apart when I sit on it? |
| 00:45:57 | Important properties - particle size distribution |
| 00:46:47 | Soils & sediments – erosion, permeability etc |
| 00:47:41 | Example - paints/coatings |
| 00:48:01 | Optical properties |
| 00:49:13 | Rubinstein (1981) |
| 00:50:01 | Example - pharmaceuticals |
| 00:50:37 | Noyes-Whitney |
| 00:50:52 | Basic simple equation |
| 00:51:13 | Noyes-Whitney (MIT) |
| 00:51:37 | Mining and minerals |
| 00:52:18 | Size effects at the nanoscale |
| 00:53:05 | Let’s not forget nano |
| 00:53:41 | Something you may not have thought of |
| 00:54:11 | Specification? |
| 00:54:50 | USP Workshop in 2010 |
| 00:55:26 | The 4 Q’s |
| 00:56:01 | Summary and advice |
| 00:56:45 | Thank you for listening |
| 01:04:37 | Thank you for your attention |
Too often, the reason for carrying out a particle size distribution analysis is stated as “for QA”, or “I need the numbers”, or “because my boss says so”, or “for characterization”. Often, we can proceed deep into a project, having acquired huge amounts of data, with no real clarity about what is driving the measurement.
This webinar explores the scientific reasons for performing a particle size distribution measurement, investigates bulk and dispersed particle sizes, and relates these to Critical Quality Attributes (CQAs) and Product Performance Indicators (PPIs).
A product flowability issue is not solved by aggressive dispersion conditions that cannot be mimicked in the plant, as these flow properties are related to the bulk - not dispersed - particle size distribution. Likewise, relating dissolution and bioavailability is best done on a dispersed sample, as most of the surface area will be available to the external continuous phase. Understanding the reasons for making such a measurement leads to the setting of reasonable and achievable product specifications that are in line with the required product performance.