| 00:00:00 | Dynamic imaging of biotherapeutic suspensions |
| 00:01:37 | Subvisible Particles in Biotherapeutic Suspensions |
| 00:01:42 | Outline |
| 00:03:21 | The Need for New Measurement Technology |
| 00:05:31 | Size Exlusion Chromatography |
| 00:07:55 | Dynamic Light Scattering Measurements |
| 00:08:52 | Imaging Measurements |
| 00:10:24 | Particles in the Microns Range… |
| 00:11:35 | Dynamic Imaging with the FPIA-3000 |
| 00:11:35 | FPIA-3000 |
| 00:12:10 | The Unique Challenge of Protein Aggregates |
| 00:14:22 | Purpose of the Sheath Flow –in Pictures |
| 00:17:51 | Image Quality |
| 00:19:55 | Why Use Sheath Flow? |
| 00:20:35 | Dynamic Imaging: Advantages and Limitations |
| 00:23:11 | Example 1: Commercial Suspensions |
| 00:24:37 | Effect of the Method of Injection on Count |
| 00:27:55 | Morphology as an Identification Tool |
| 00:28:36 | Morphology as an Identification Tool |
| 00:30:11 | Discriminating Power |
| 00:31:34 | Discriminating Power |
| 00:33:25 | Morphology… if you can see the particle! |
| 00:36:19 | Example 2: Investigating the Stability of Suspensions |
| 00:38:28 | What Types of Particles Are Formed? |
| 00:40:08 | Measuring High-Concentration Suspensions |
| 00:41:15 | Protein Particulates or Not? |
| 00:42:44 | Dynamic imaging of BSA +Urea |
| 00:43:38 | Example 3: Static Imaging + Chemical Identification |
| 00:45:58 | Looking Similar Doesn’t Mean They Are the Same… |
| 00:47:44 | Example of Particle and Chemical Signature |
| 00:48:11 | Conclusions |
| 00:50:32 | Strategies to Increase Particle Detection and Identify |
| 00:53:00 | Contact information |
| 00:58:24 | Contact Information |
This webinar discusses some of the reasons why the use of dynamic imaging grew rapidly in small molecule pharmaceutical laboratories and the parameters which must be considered in the selection of a dynamic imaging method.