Synthesising PEGylated proteins? Need rapid decision making?

Meet the world’s most advanced multi-detector GPC/SEC system, the OMNISEC.  Malvern Panalytical’s OMNISEC is a Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters.

This multi-detection SEC also enables composition analysis, which exploits the combination of the two concentration detectors, refractive index (RI) and UV-Vis, to determine the concentration of the two components on a sample. This, combined with the data from right angle or low angle light scattering (RALS/LALS) or multi-angle light scattering (MALS) detectors, and the online differential viscometer detector, allows for a full and accurate characterization of a conjugated sample.

So what do this mean for me?

• full characterization of PEGylated proteins, and in general of conjugated samples
• understanding of the successfulness of the PEGylation reaction and the composition of the PEGylated protein product
• fast turnaround of the process, including reaction optimization and straightforward SEC characterization
• no need to wait for lengthy purification steps to characterise your product
• empowerment to make fast decisions when optimizing the production of a product

Want to learn more?  Read our application note to see how OMNISEC can give you full compositional analysis and save you time by analysing crude PEGylation reaction mixtures, allowing you rapid decision making.