动态光散射 (DLS)，有时称为准弹性光散射 (QELS)，是一种成熟的非侵入技术，可测量亚微米范围内的分子与颗粒的粒度及粒度分布，它使用最新技术，可测粒度可小于 1nm。
DLS的应用
动态光散射的典型应用是对分散于或溶解于液体的颗粒、乳剂或分子进行表征。
悬浮在溶液中的颗粒的布朗运动，造成散射光光强的波动。
分析光强的波动得到颗粒的布朗运动速度，再通过斯托克斯-爱因斯坦方程得到粒度。
Pharmaceuticals and Biotechnology
The Zetasizer Advance is instrumental in nanoparticle characterization for drug delivery systems, ensuring precise size distribution analysis crucial for drug efficacy and stability.
It facilitates the study of protein aggregation kinetics, enabling researchers to optimize protein formulations and ensure product quality in biopharmaceutical manufacturing.
Cosmetics and Personal Care
In the cosmetics industry, the Zetasizer Advance helps in characterizing the size and stability of colloidal dispersions, essential for the formulation of creams, lotions, and emulsions.
It aids in assessing the stability of nanoparticles in sunscreen formulations, ensuring effective UV protection and long-term stability of the product.
Food and Beverages
The Zetasizer Advance assists in analyzing the particle size distribution and aggregation behavior of food emulsions, influencing product texture, stability, and sensory attributes.
It is used to evaluate the stability of colloidal suspensions in beverages, ensuring product clarity and shelf-life stability.
Materials Science and Nanotechnology
In materials science, the Zetasizer Advance is employed for nanoparticle sizing and characterization, guiding the synthesis and optimization of functional nanomaterials for diverse applications.
It aids in studying the stability and aggregation kinetics of nanoparticles in coatings and composites, influencing material properties such as mechanical strength and optical transparency.
Environmental Monitoring
The Zetasizer Advance contributes to environmental monitoring efforts by analyzing the size distribution and aggregation behavior of nanoparticles in environmental samples, helping assess their impact on ecosystems and human health.
It aids in studying the behavior of engineered nanoparticles in wastewater treatment processes, ensuring efficient removal and minimizing environmental exposure.
DLS技术优势
Malvern Panalytical 提供的动态光散射技术具有以下优势：
- 准确、可靠、可重复的粒度分析，只需一到两分钟即可完成
- 多角动态光散射 (MADLS) 可提高 DLS 的分辨率并提供不受角度影响的粒度结果
- 对每个颗粒浓度峰值进行简单、不受材料影响的测量
- 只需了解液体粘度即可得出平均粒度
- 简便的样品备制，或无需备制，可直接使用 NIBS 对高浓度混浊样品进行测量
- 粒度测量范围为 <1 nm 至 >10 um
- 可进行 MW < 1000 Da 的分子粒度测量
- 样品需求量低（低至 3 µL）
- 可用于控制纳米颗粒制造的在线流程系统
- 符合法规性标准 ISO 13321、ISO 22412、联邦法规第 21 章 11 款
