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The stability of monoclonal antibodies (mAbs) is a key parameter in their development as therapeutics. The rapid and accurate assessment of antibody stability is of major interest to researchers and manufacturers to ensure the consistency of the mAb therapeutics in terms of their specificity and affinity. In collaboration with Protein Stable and Malvern Panalytical, Concept Life Sciences ...

扩散屏障法是一种通过最小化测量过程的影响来可靠地测量蛋白质电泳迁移率的方法。蛋白质与施加电场所用的电极接触会导致样品发生变性和聚集，导致Zeta电位明显变化。本文记录Zetasizer纳米粒度电位仪利用扩散屏障法将样品分子与电极分离，可以很好地避免电极接触对蛋白质测量的影响。

In viral vector formulation development, it is often assumed that the purification process is effective and that all vectors are formed as expected. However, this is not always the case. What if specific vector components could be tagged to detect and confirm their presence? This application note demonstrates how a specific, two-step labeling process can be used to detect VSV-G positive lentivirus ...

A common method for detecting and studying cell behavior is fluorescence detection, which can also be applied to characterize much smaller viral vectors. This application note demonstrates how membrane labeling, using lipophilic dyes, can be used to characterize viral vector formulations with NanoSight Pro fluorescence mode. Please login or register for free to learn more.

One of the primary goals in formulation development is to achieve a high titer with excellent product stability. However, performing titer analysis using traditional bioassays is challenging and time consuming. This application note demonstrates how NanoSight Pro, utilizing Nanoparticle Tracking Analysis (NTA) technology, with its fast measurement capabilities and minimal sample preparation, ...

In the development of viral vector formulations, quickly assessing sample purity is essential because it directly affects the vector’s properties and performance. This application note demonstrates how NanoSight Pro, utilizing Nanoparticle Tracking Analysis (NTA) technology, can serve as an efficient alternative to bioassays for rapid and effective characterization of virus purity and heterogeneity. ...

Lentivirus is a popular viral vector used in gene therapy development. It has several advantages over other viral and non-viral vector-based gene therapies, including the ability to transport large or multiple genes to the target cell, infect both dividing and non-dividing cells, and integrate transgenes into the host cell genome. However, these desirable Lentiviral vector properties require ...

Lentivirus is a widely used viral vector in gene therapy. It offers several advantages over other viral and non-viral vectors, such as the ability to carry large or multiple genes into target cells, infect both dividing and non-dividing cells, and integrate transgenes directly into the host cell’s genome. However, these desirable Lentiviral vector properties require a more complex structure ...

Lentivirus is a popular viral vector used in gene therapy development. It has several advantages over other viral and non-viral vector-based gene therapies, including the ability to transport large or multiple genes to the target cell, infect both dividing and non-dividing cells, and integrate transgenes into the host cell genome. However, these desirable Lentiviral vector properties require ...

Lentivirus is a popular viral vector used in gene therapy development. It has several advantages over other viral and non-viral vector-based gene therapies, including the ability to transport large or multiple genes, infect both dividing and non-dividing cells, and integrate transgenes into the host cell genome. However, these desirable lentiviral vector properties require a more complex ...